Author Archives: eastepp

Understanding MTHFR Gene Mutation: Impact on B12 Metabolism

july 11, 2024:

The 5-MTHFR gene mutation affects the body’s ability to process folate and can impact B12 metabolism. Here’s how the mutation and B12 are connected:

MTHFR Gene and Its Function:

•MTHFR (Methylenetetrahydrofolate Reductase): This enzyme plays a critical role in the process of converting homocysteine (an amino acid that is obtained as a by product of methionine metabolism that plays a particular role in methylation in the body as well as transulfurtation pathways), a building block for proteins.

•Folate Metabolism: MTHFR helps convert folate (vitamin B9) into its active form, 5-MTHF (5-methyltetrahydrofolate), which is used in various biochemical reactions, including DNA synthesis and repair.

Impact of MTHFR Mutation:

•Reduced Enzyme Activity: Individuals with MTHFR mutations have reduced enzyme activity, leading to elevated homocysteine levels and decreased levels of 5-MTHF.

•Methylation Process: The mutation impairs the methylation cycle, a process crucial for DNA synthesis, repair, and gene expression.

Connection to Vitamin B12:

•Homocysteine Reduction:Vitamin B12 works alongside folate in the conversion of homocysteine to methionine. A deficiency in either nutrient can lead to elevated homocysteine levels, which are associated with cardiovascular risks.

•Methylcobalamin: One of the active forms of vitamin B12, methylcobalamin, directly participates in the methylation cycle. People with the MTHFR mutation may benefit from supplementing with this form of B12, as it is already in a bioactive state.

Considerations for Those with MTHFR Mutation:

•Supplementation: Individuals with MTHFR mutations might need to take methylated forms of B vitamins, such as methylfolate (active form of folate) and methylcobalamin (active form of B12), to support proper methylation and reduce homocysteine levels.

•Dietary Sources: Ensuring adequate intake of B vitamins through diet can also be beneficial. Foods rich in B12 include animal products like meat, fish, eggs, and dairy. For folate, leafy green vegetables, legumes, and fortified foods are good sources.

By understanding the interplay between the MTHFR mutation and B12, individuals can better manage their nutrient intake to support overall health and mitigate potential risks associated with impaired methylation processes.

Functions of Homocysteine: (an amino acid that is obtained as a by product of methionine metabolism)

Cardiovascular Health

1. Elevated homocysteine levels (hyperhomocysteinemia) are associated with an increased risk of cardiovascular diseases, including coronary artery disease, stroke, and peripheral vascular disease. High homocysteine can damage blood vessels, promote atherosclerosis, and increase the risk of blood clots.

2. Transsulfuration Pathway: Homocysteine can also be converted into cysteine through the transsulfuration pathway, which requires vitamin B6. Cysteine is a precursor to glutathione, a major antioxidant that protects cells from oxidative stress and supports detoxification.

Homocysteine and Health:

While homocysteine itself has no direct function in bodily processes, its levels can significantly impact health:

1. Neurological Health: Elevated homocysteine levels have been linked to cognitive decline, dementia, and Alzheimer’s disease. Homocysteine can induce neurotoxicity, oxidative stress, and impair DNA repair mechanisms in the brain.

Factors Influencing Homocysteine Levels:

• Diet: Insufficient intake of vitamins B6, B12, and folate can lead to elevated homocysteine levels.

• Genetics: Mutations in the MTHFR gene can impair homocysteine metabolism, leading to higher levels in the blood.

• Lifestyle: Smoking, excessive alcohol consumption, and lack of physical activity can contribute to increased homocysteine levels.

• Medical Conditions: Kidney disease, hypothyroidism, and certain genetic disorders can also affect homocysteine metabolism.

Managing Homocysteine Levels:

To maintain healthy homocysteine levels, it is essential to ensure adequate intake of vitamins B6, B12, and folate through a balanced diet or supplementation if necessary. Regular monitoring and addressing underlying health conditions can also help manage homocysteine levels and reduce associated health risks.

I have been using Triquetera’s 5-MTHR L-Methylfolate 15mg in both the pills and sublingual drops:

Triquetra 15mg Capsules – L-Methylfolate 5-MTHF
Triquetra 15mg Sublingual Drops – L-Methylfolate 5-MTHF
https://stpetehw.com/methylation-mthfr-and-associated-diseases-by-les-cole-md/
sources from St. Pete Health & Wellness

hospital stay costs $32,656.

I had to go to the hospital on 6/16 for a mental health issue where I was not given any surgeries, procedures, or anything that would medically warrant a bill this large. I have health insurance and the hospital billed my insurance $32,656.24, of which the insurance has supposedly paid for. that leaves a “pending insurance” balance which is what really scares me, but if so than I would def meet my out of pocket max deductible of $1,800.00 which I am already close to. The only good thing about this health insurance is that I haven’t paid for a prescription ALL year. all free at the pharmacy. well, my precious Tretinoin (Retin-A) 0.025% cream was denied by my insurance company when I have been on it for YEARS. I switched to azelaic acid because I wanted to try something new, it was $8/mo when I had Cigna. I decided to just pay out of pocket and it was $36.00. Honestly makes you appreciate and use it more lol. I am waiting for Ambetter to send all of my EOB’s so I can comapare them to what the hospital billed & I hope that the hospital gets my financial assistance application like the lady said they would and I would qualify for 100% assistance. (I got laid off on 5/31, I got my last half paycheck on 6/14 and am waiting on unemployment). Cannot believe that I had a $30K+ trip to the hospital & don’t even have new teeth or better. Only if you have it, please consider donating and I will show you the receipt of it going to the bills below which I downloaded straight from MyChart.

July 10, 2024.

mental health awareness:

june 16 to june 20, 2024:

my 5 days in the hospital:

I was laid off from my job on May 31, 2024. We got our official paperwork on May 20, 2024. We had been told that it was coming but they just kept extending it, acting like the NEEDED us and that basically, until the client says we gotta go, we’re staying.

Around June 5 or 6, I started to feel extremely depressed and was crying for no reason and had no idea why but also my entire routine had been taken from me and I now went from working my ass off every single day to doing nothing. I felt purposeless and like I had no place. I felt devalued and complete disposed of. We were laid off over Zoom from our office and signed our paperwork stating that we would be eligible for unemployment and that they would NOT be contesting it.

A few of my co-workers that were in the phases before I was, meaning they were laid off first, advised me NOT to apply for unemployment until I got my final check, my severance check. For some reason, the last group of us got our severance pay and our last weeks paycheck and vacation hours all on the same day. I applied for unemployment around June 20, 2024.

I have officially been unemployed since May 31 of 2024 and have applied for unemployment as well as food stamps and have not heard anything back from either agency. I have not received a paycheck since June 14 and that was 2 days before I was admitted to the hospital. Luckily, I wasn’t able to spend a lot of money during my hospital stay because I wasn’t awake for most of it. The doctors said that I was extremely dehydrated and malnourished, which was true because I definitely had not eaten a full meal in 10 days.

I say all of this to say that I ended up in the hospital for a nervous breakdown because of a corporation that discarded me like trash. they have not done anything as promised and that is the way of corporate America. We are so lucky these days because we have so many other ways and opportunities to make money and make a lot of it. That is part of the reason that I started this website. I am still in the very beginning stages, but I want to provide people freedom from their 9 to 5 jobs because we were not put on this earth to be slaves to other humans.

june 21, 2024

l-methylfolate 15mg

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mental health

everyone at some point in their life will struggle with their mental health. people sometimes look at their mental health as a weakness, but often it is our greatest strength. I have always been very open and candid regarding my struggles with mental health and addiction.

1 out of 5 americans will struggle with their mental health or depression at some time in their life. [healthgrades.com]

addiction and mental health:

addictive behaviors lack of impulse control, inability to quit doing a task that is harming you, etc drinking; smoking

taking th edge off: L-Methylfolate is an amazing supplement that takes your mind off of everything while giving you a boost of seratonin and dopamine.